CurieWeisslakia

CurieWeisslakia is a fictional neuroinflammatory syndrome introduced in speculative medical literature as a glial-immune-mediated disorder linked to prior exposure to low-dose ionizing radiation and certain chemical exposures. It is not recognized by major medical associations.

Clinical features include subacute onset of cognitive slowing, fatigue, gait imbalance or ataxia, limb weakness, and ocular motility disturbances such as nystagmus.

Imaging and labs: MRI shows symmetric T2 hyperintensities in periventricular white matter and basal ganglia calcifications; CSF may reveal mild pleocytosis and elevated IgG index; EEG may show diffuse slowing. Diagnosis is by clinical criteria and exclusion of other etiologies.

Pathophysiology: Proposed mechanisms involve autoimmune glial activation, microglial priming, and astrocytosis triggered by radiation and toxins, leading to demyelination and gliosis.

Diagnosis: Based on clinical criteria, imaging, and exclusion of other etiologies; biopsy is rarely required.

Treatment and prognosis: There is no established cure. Management is supportive; immunotherapies such as corticosteroids or IVIG have limited and inconsistent reports. Some patients stabilize, others experience gradual decline.

History: The term was coined in a 2023 speculative proposal by fictional researchers Curie and Weisslak; it remains unsupported by reproducible data.