Crklike
Crklike refers to a family of protein-tyrosine kinases that play crucial roles in cell signaling pathways. These kinases are characterized by their conserved kinase domain, which is responsible for phosphorylating target proteins. The name "Crklike" is derived from the observation that these proteins share structural and functional similarities with CRK (Chicken embryo-related kinase), a well-known proto-oncogene.
Members of the Crklike family, such as CRKL, ABL, and others, are involved in a variety of
Dysregulation of Crklike kinases has been implicated in the development and progression of various diseases, particularly