CpGmotief
CpGmotief refers to a CpG dinucleotide sequence in DNA, where a cytosine (C) is immediately followed by a guanine (G) in the 5' to 3' direction. These sequences are often found in clusters, known as CpG islands, which are typically located in or near the promoter regions of genes. In mammals, CpG dinucleotides are frequently methylated, a process catalyzed by DNA methyltransferases. This methylation usually occurs on the cytosine residue.
The methylation of CpG motifs plays a crucial role in gene regulation. Unmethylated CpG islands are generally
Aberrant CpG methylation patterns are implicated in several diseases, most notably cancer. Hypermethylation of CpG islands