CdtB
cdtB is the gene encoding the catalytic subunit of the cytolethal distending toxin (CDT) produced by several Gram-negative bacteria. In CDT operons, cdtA, cdtB, and cdtC encode the three subunits required for activity, with CdtB functioning as the enzymatic component that damages host DNA.
Biochemical activity and effects: CdtB is a Mg2+- or Ca2+-dependent DNase I–like enzyme that introduces double-strand
Delivery and mechanism of action: The CDT holotoxin binds to host cells via the CdtA and CdtC
Genetics and distribution: cdtB is found in a range of pathogenic bacteria, including Campylobacter species and
Clinical and pathogenic relevance: CDT has been associated with cytopathic effects in cultured cells and is
Relation and structure: CdtB shares homology with DNase I family enzymes and requires metal cofactors for catalysis;