Cdc25fosfataser
Cdc25 fosfataser, often written as Cdc25 phosphatases in English, are a family of dual-specificity protein phosphatases that regulate cell cycle progression in eukaryotic cells by activating cyclin-dependent kinases (CDKs). They achieve this primarily by dephosphorylating inhibitory phosphates on CDKs, particularly at Tyr15 and, in some contexts, Thr14, thereby enabling entry into mitosis or S phase depending on the isoform and cellular context.
In humans, the CDC25 family includes CDC25A, CDC25B, and CDC25C, with overlapping but distinct roles. CDC25A
Biochemically, CDC25 enzymes are dual-specificity phosphatases containing a catalytic HCX5R motif in their active site and
Dysregulation of CDC25 proteins is associated with cancer, where overexpression or aberrant regulation can drive unchecked