Captisol

Captisol is the brand name for a specific type of cyclodextrin known as sulfobutylether beta-cyclodextrin (SBE-β-CD). Cyclodextrins are cyclic oligosaccharides derived from starch. Captisol's unique chemical structure allows it to form molecular complexes with other molecules, effectively encapsulating them within its ring-like structure. This inclusion complex formation is the basis for its utility.

The primary application of Captisol is in the pharmaceutical industry as an excipient. Excipients are inactive ingredients used in drug formulations to help deliver the active pharmaceutical ingredient. Captisol is particularly useful for improving the solubility of poorly water-soluble drugs. By complexing with these drugs, Captisol increases their apparent solubility in aqueous solutions, which can enhance their absorption and bioavailability in the body. This can lead to more effective drug delivery and potentially lower required doses.

Captisol is also used to stabilize certain drugs, protecting them from degradation caused by factors like oxidation or hydrolysis. It can also mask the taste of unpleasant-tasting medications, making them more palatable for patients. Its use is well-established in various injectable and oral drug products. The safety and efficacy of Captisol have been evaluated by regulatory agencies, and it is approved for use in a range of pharmaceutical applications.