CadiotChodkiewicz
The Cadiot-Chodkiewicz coupling is a chemical reaction used to form a new carbon-carbon bond between a terminal alkyne and a haloalkyne. This reaction is a variation of the Glaser coupling and allows for the synthesis of unsymmetrical diynes. The reaction typically involves the use of a copper(I) catalyst, often in the presence of a base such as an amine.
The general mechanism involves the deprotonation of the terminal alkyne by the base, forming a copper(I) acetylide.
This reaction is particularly useful in organic synthesis when it is desired to couple two different alkyne