CF3CFO2SONH2

CF3CFO2SONH2, also known as trifluoromethanesulfonylamide, is an organosulfur compound with the chemical formula CF3SO2NH2. It is a white crystalline solid at room temperature and is soluble in many organic solvents. The compound features a trifluoromethyl group (CF3) attached to a sulfonyl group (SO2), which is in turn bonded to an amide group (NH2).

Trifluoromethanesulfonylamide is structurally related to trifluoromethanesulfonic acid (triflic acid), a very strong acid. The presence of the highly electronegative trifluoromethyl group significantly increases the acidity of the amide proton compared to simple amides. This property makes it a useful reagent in organic synthesis.

In organic chemistry, trifluoromethanesulfonylamide can act as a source of the trifluoromethanesulfonyl group. It is employed in various reactions, including the synthesis of triflates and other sulfonamide derivatives. Its unique electronic properties allow for specific chemical transformations and the introduction of the trifluoromethanesulfonyl moiety into complex molecules. Research has explored its potential applications in areas such as materials science and medicinal chemistry due to the distinct characteristics conferred by the trifluoromethyl group.