CDKentsyymit
CDKentsyymit, or cyclin-dependent kinases (CDKs), are a family of conserved serine/threonine protein kinases in eukaryotic cells. Their catalytic activity depends on association with regulatory cyclin proteins. In the absence of cyclins, most CDKs are largely inactive; binding to a specific cyclin induces conformational changes that enable substrate recognition and activation. Activation is further governed by phosphorylation events and by inhibitors that modulate activity.
In humans, CDKs include several members with distinct roles. CDK1, in complex with cyclin B, drives the
Regulation of CDKs involves activation by phosphorylation of a key threonine residue in the activation loop