CD3targeted
CD3targeted refers to therapeutic and research strategies that engage the CD3 complex on T cells to influence immune responses. CD3 is a component of the T cell receptor signaling machinery, associated with the TCR through CD3γ, CD3δ, and CD3ε chains. By binding CD3, these approaches can activate, deplete, or redirect T cells depending on the modality and context.
Monoclonal antibodies against CD3 have been used to modulate T cell activity. Muromonab-CD3 (OKT3) was the first
CD3 is also a central component of T cell engaging therapies. Bispecific antibodies that bind CD3 on
Clinical use of CD3-targeted therapies reflects a balance between potential efficacy and safety, with ongoing research