CD147Basigin

CD147, also known as Basigin or EMMPRIN, is a type II transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is widely expressed on the surface of various cell types, including epithelial cells, endothelial cells, lymphocytes, and tumor cells. CD147 plays a crucial role in a multitude of biological processes, including cell adhesion, cell migration, cell proliferation, and signal transduction.

One of the key functions of CD147 is its interaction with extracellular matrix metalloproteinases (MMPs). By binding to MMPs, CD147 can modulate their activity, influencing processes such as tissue remodeling, wound healing, and angiogenesis. This interaction is particularly relevant in the context of cancer, where CD147 is often overexpressed in tumor cells and is associated with tumor invasion, metastasis, and resistance to chemotherapy.

CD147 also participates in immune responses. It is involved in T cell activation and differentiation, as well as the regulation of B cell function. Furthermore, CD147 has been implicated in the development of inflammatory conditions.

Due to its diverse roles in cellular processes, particularly in cancer progression, CD147 has emerged as a potential therapeutic target. Strategies aimed at inhibiting CD147 activity or expression are being explored for the treatment of various cancers and other diseases.