CD117positive

CD117positive refers to a specific marker used in the field of immunology and hematology to identify a particular type of cell. CD117 is a protein encoded by the KIT gene, which is a receptor tyrosine kinase. This marker is commonly associated with stem cells and their progeny, particularly in the context of hematopoietic stem cells (HSCs) and their differentiation into various blood cell types.

The CD117 antigen is expressed on the surface of cells that are positive for the CD117 marker. This includes HSCs, multipotent progenitors, and some mature blood cells. The CD117 marker is often used in flow cytometry and immunohistochemistry to identify and isolate these cells for research, diagnostic, or therapeutic purposes.

In clinical settings, CD117 positivity is particularly relevant in the diagnosis and treatment of certain types of cancer. For example, it is used to identify stem cells in leukemia and other hematopoietic malignancies. The presence of CD117-positive cells can indicate the presence of a specific subtype of cancer, such as acute myeloid leukemia (AML) or gastrointestinal stromal tumors (GISTs).

The CD117 marker is also utilized in stem cell transplantation, where CD117-positive cells are often targeted for isolation and expansion to create a bank of stem cells for future use. This is crucial for patients undergoing chemotherapy or radiation therapy, as it allows for the preservation of their hematopoietic stem cells.

In summary, CD117positive is a valuable marker in the study and treatment of hematopoietic cells and their related disorders. Its ability to identify stem cells and their progeny makes it an essential tool in both research and clinical practice.