CBDa

CBDA, or cannabidiolic acid, is a cannabinoid found in the cannabis plant as the acidic precursor to cannabidiol (CBD). In Cannabis sativa and related species, CBDA is produced in the plant’s glandular trichomes from cannabigerolic acid (CBGA) by the enzyme CBDA synthase. It is the predominant cannabinoid in fresh, unheated plant material, while heating or aging promotes decarboxylation, converting CBDA to CBD and releasing carbon dioxide.

Chemically, CBDA contains a carboxyl group that is removed during decarboxylation. This reaction is accelerated by heat, light, and time. Consequently, raw cannabis contains mainly CBDA, whereas most CBD-dominant products are produced by decarboxylating CBDA to CBD.

Pharmacology and research: CBDA is non-psychoactive and has little affinity for the CB1 receptor. Some laboratory and animal studies have suggested CBDA may have antiemetic and anti-inflammatory properties. Human data remain limited, and researchers emphasize that results from isolated CBDA may differ from those observed with whole-plant extracts containing multiple cannabinoids.

Uses and preparation: CBDA is commonly preserved in raw cannabis preparations, such as whole-plant extracts or raw preparations consumed as juice, to deliver CBDA along with other non-psychoactive cannabinoids. In most CBD products, CBDA is converted to CBD through decarboxylation, typically by heating during processing or consumption.

Stability and storage: CBDA can decarboxylate over time, and prolonged exposure to heat and light reduces CBDA content. It is one of several acidic cannabinoids found in raw plant material and is frequently studied as part of the broader cannabis cannabinoid profile.