CAPZB12

CAPZB12 is a putative isoform of the β subunit of the CapZ actin-capping protein complex. In the canonical CapZ complex, CapZ consists of α and β subunits (CAPZA and CAPZB) and binds the barbed end of actin filaments to regulate polymerization dynamics.

CAPZB12 has been described in a few transcript repositories as a splice variant of CAPZB. Functional characterization is limited; there are no published experimental studies confirming its expression at the protein level or its specific biochemical properties. Bioinformatic predictions suggest that CAPZB12 would retain the conserved C-terminal actin-binding regions, but may carry sequence differences in the N-terminal region that could influence subcellular localization or interaction with CAPZA.

Specifically, CAPZB12 is predicted to localize to the cytoplasm and to actin-rich structures such as lamellipodia or stress fibers, where CapZ is typically found. Its exact role, if any, in actin filament capping, regulatory signaling, or cell migration remains unclear.

In the absence of robust experimental data, CAPZB12 is not established as a distinct functional entity in most species, and its nomenclature varies across databases.

Related topics include CapZ and actin cytoskeleton regulation.