CADM14

CADM14, or cell adhesion molecule 14, is referenced as a member of the CADM family of immunoglobulin-like cell adhesion molecules. Compared with the better-characterized CADM1–CADM4, CADM14 is poorly documented in public databases, and there is limited peer-reviewed literature detailing its gene structure, expression, or function.

Genomic context varies across resources. CADM14 has appeared in some vertebrate genome assemblies, but its status as a distinct, protein-coding gene in humans is not consistently annotated. Some annotations treat CADM14 as an alias of another CADM family member or as an unverified locus, reflecting ongoing uncertainty about its exact gene model and coding status.

Protein-coding potential for CADM14 is predicted to yield a single-pass transmembrane glycoprotein with extracellular immunoglobulin-like domains and a relatively short cytoplasmic tail. If expressed, it would be expected to act as an adhesion receptor within the immunoglobulin superfamily, potentially mediating homophilic and heterophilic interactions and contributing to cell–cell adhesion, signaling, and the organization of tissue architecture or synaptic contacts.

Expression data for CADM14 are scarce and occasionally conflicting across studies and species. Where detected, transcripts or proteins are reported in neural or epithelial contexts, but there is no robust, reproducible tissue- or developmental expression profile.

Clinical relevance remains unsettled. There are no established disease associations or diagnostic applications for CADM14, and any proposed links require further validation through targeted functional and genetic investigations.

Overall, CADM14 is a putative CADM family member with limited, inconsistent evidence for its existence and function. Researchers should consult current genome annotations and primary literature for the latest characterization.