Biokompatibilised
Biokompatibilised (also biocompatibilized) describes materials, devices, or surfaces that have been modified to exhibit compatibility with living tissues and biological systems. The goal of biokompatibilisation is to reduce adverse reactions such as inflammation, immune rejection, cytotoxicity or thrombosis while maintaining the intended mechanical and functional properties.
Methods for biokompatibilisation include surface coatings (e.g., hydrophilic polymers, titanium oxide, bioactive ceramics), chemical functionalization (e.g.,
Common applications are medical implants (orthopaedic, dental, cardiovascular), tissue engineering scaffolds, biosensors, and drug delivery vehicles.
Assessment of biokompatibilised products follows in vitro assays (cytotoxicity, hemocompatibility, protein adsorption), in vivo models, and
Challenges include ensuring long-term stability of the modification, avoiding unintended effects on mechanical properties, and balancing