BCL10s

BCL10s, also known as B-cell lymphoma 10, is a protein that plays a crucial role in the regulation of cell survival and proliferation. It is a member of the BCL10 family of proteins, which includes BCL10, BCL10L1, and BCL10L2. BCL10s is primarily expressed in B cells, where it functions as a transcriptional co-activator, interacting with various transcription factors to regulate gene expression.

The BCL10s protein is characterized by its ability to bind to the p65 subunit of NF-κB (nuclear factor-kappa B), a transcription factor that regulates the expression of genes involved in inflammation, immune response, and cell survival. This interaction is essential for the activation of NF-κB, which is a critical pathway in the regulation of immune responses and inflammation.

BCL10s has been implicated in various biological processes, including B cell development, immune response, and cancer. In B cell lymphomas, BCL10s is often overexpressed, contributing to the uncontrolled proliferation of B cells. This overexpression can lead to the development of diffuse large B-cell lymphoma (DLBCL), a type of non-Hodgkin lymphoma characterized by the presence of a specific genetic rearrangement involving the BCL10 gene.

Research on BCL10s is ongoing, with studies focusing on its role in cancer development and potential as a therapeutic target. Understanding the molecular mechanisms underlying BCL10s function and its interaction with NF-κB may provide new insights into the pathogenesis of B cell lymphomas and other related diseases.