Asn40Asp
Asn40Asp is a shorthand notation used in protein and genetic contexts to describe a missense substitution in which asparagine (N) at position 40 of a protein is replaced by aspartic acid (D). The same change may be written as N40D or N40→D. The impact of such a substitution is highly dependent on the specific protein and its structural and functional context.
Asparagine is a neutral, polar amino acid, while aspartic acid carries a negative charge at physiological pH.
Assessing the consequence of an Asn40Asp change typically involves multiple lines of evidence. Sequence conservation at
Overall, Asn40Asp is a context-dependent variant. Its significance varies with the gene and protein involved, and