Androgéndepriváció

Androgéndepriváció refers to the deprivation or reduction of androgens, which are a group of steroid hormones that play a role in the development and maintenance of male characteristics. The most well-known and potent androgen is testosterone. Androgens are produced in significant amounts by the testes in males and in smaller amounts by the adrenal glands in both sexes. They are crucial for various bodily functions, including the development of reproductive tissues, secondary sexual characteristics, and bone density.

In a medical context, androgen deprivation therapy (ADT), also known as hormonal therapy, is a treatment strategy primarily used to manage hormone-sensitive cancers, most notably prostate cancer. This therapy aims to lower the levels of androgens in the body, thereby slowing or stopping the growth of cancer cells that rely on these hormones for proliferation. ADT can be achieved through various methods, including medications that block androgen production or action, or surgical removal of the testes (orchiectomy), which are the primary source of androgens.

While effective in treating certain cancers, androgen deprivation can lead to a range of side effects due to the reduction in androgen levels. These can include hot flashes, decreased libido, erectile dysfunction, fatigue, loss of muscle mass, weight gain, and a potential increase in the risk of osteoporosis and cardiovascular issues. The management of these side effects is an important aspect of patient care during ADT.