ANAPG70

ANAPG70 is a protein that in humans is encoded by the ANAPC7 gene. This gene is a member of the anaphase-promoting complex/cyclosome (APC/C) family, which plays a crucial role in the regulation of the cell cycle. The APC/C complex is involved in the degradation of various substrates, including cyclins and cyclin-dependent kinases (CDKs), which are essential for cell cycle progression.

The ANAPC7 gene encodes a subunit of the APC/C complex, specifically the anaphase-promoting complex subunit 7 (APC7). APC7 is a key component of the APC/C complex, which is responsible for targeting substrates for degradation by the 26S proteasome. This process is crucial for ensuring that cells progress through the cell cycle in an orderly manner and that damaged or unnecessary proteins are removed.

Mutations in the ANAPC7 gene have been associated with various diseases, including certain types of cancer. For example, loss-of-function mutations in ANAPC7 have been observed in breast cancer, suggesting that the APC/C complex may play a role in tumor suppression. Additionally, gain-of-function mutations in ANAPC7 have been linked to other types of cancer, highlighting the complex and multifaceted role of this protein in cellular processes.

Research into the ANAPC7 gene and its encoded protein continues to uncover new insights into the mechanisms of cell cycle regulation and cancer development. Understanding the functions of ANAPC7 and the APC/C complex more broadly is essential for developing targeted therapies for cancer and other diseases.