ANAPC7

ANAPC7, also known as APC-Interacting Protein 7, is a protein encoded by the ANAPC7 gene in humans. It is a core component of the Anaphase-Promoting Complex/Cyclosome (APC/C), an essential multi-protein E3 ubiquitin ligase that regulates cell cycle progression, particularly during mitosis and the exit from mitosis. The APC/C orchestrates the degradation of key cell cycle regulators, such as securin and cyclins, thereby ensuring proper chromosome segregation and cell division.

The ANAPC7 protein contributes to the assembly and stability of the APC/C complex. It interacts with other core subunits, facilitating the recognition and ubiquitination of target substrates. Its function is critical for activating the APC/C during specific cell cycle phases, especially in the transition from metaphase to anaphase.

Research indicates that the proper functioning of ANAPC7 is vital for maintaining genomic stability. Mutations or dysregulation of this protein have been linked to chromosomal instability, which can contribute to oncogenesis. In cancer biology, abnormal expression or mutations of APC components, including ANAPC7, have been observed in various tumor types, highlighting its potential role in tumor suppression and cell cycle control.

Structurally, ANAPC7 is characterized by specific domains that enable interactions with other APC/C subunits and regulatory proteins. Its precise molecular mechanisms are an active area of research, aiming to better understand how it contributes to cell cycle regulation and its implications in disease states.

Overall, ANAPC7 is a crucial protein within the cell cycle regulation machinery, underpinning proper cell division and genomic integrity through its role in the APC/C complex.