A2AR
Adenosine A2A receptor (A2AR) is a G protein-coupled receptor that mediates the actions of the purine nucleoside adenosine. In humans it is encoded by the ADORA2A gene. A2AR belongs to the A2A adenosine receptor subtype, one of four adenosine receptor families (A1, A2A, A2B, A3).
Expression is highest in the striatum of the brain, particularly in neurons of the indirect pathway of
A2AR couples to heterotrimeric Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP, which activates protein
Physiological and clinical relevance includes modulation of motor function and cardiovascular and immune processes. Antagonists of