9THC

9THC, commonly written as Δ9-THC, refers to delta-9-tetrahydrocannabinol, the principal psychoactive component of cannabis. It is a lipophilic phenolic compound found in Cannabis sativa and related species. The chemical formula is C21H30O2, and it exerts its effects primarily by activating cannabinoid receptors in the central nervous system.

Mechanism and effects: acts as a partial agonist at CB1 receptors and, to a lesser extent, CB2; responsible for euphoria, altered perception, analgesia, appetite stimulation, and impairments in memory and coordination.

Pharmacokinetics: rapidly absorbed after inhalation, slower after oral ingestion; extensively metabolized in the liver to active metabolite 11-hydroxy-THC; elimination: long half-life, stored in adipose tissue; excretion mainly in feces and some in urine.

Medical and legal status: used medically for nausea, loss of appetite, chronic pain, but not approved as a sole drug in many places; synthetic analogs exist; global regulation varies; in the United States, Δ9-THC is federally classified as a Schedule I substance; many jurisdictions permit medical or recreational use.

Safety and adverse effects: impairment of cognitive and motor function; risk of anxiety or paranoia; potential for dependence with heavy use; withdrawal symptoms mild; risk of psychosis in predisposed individuals.