5HT1familien
The 5HT1 family refers to a group of serotonin receptors, specifically subtypes 5HT1A, 5HT1B, 5HT1D, 5HT1E, and 5HT1F. These receptors are G protein-coupled receptors that play a significant role in the central nervous system and other tissues. Serotonin, also known as 5-hydroxytryptamine (5HT), is a neurotransmitter involved in regulating mood, appetite, sleep, and other physiological processes. The 5HT1 family receptors are primarily inhibitory, meaning their activation generally leads to a decrease in neuronal activity.
The 5HT1A receptor is widely distributed in the brain and is implicated in anxiety, depression, and cognition.
Pharmacological agents targeting the 5HT1 family receptors have been developed for various therapeutic purposes. For instance,