4Methoxyacetophenone

4-Methoxyacetophenone, also known as acetanisole or p-acetanisole, is an organic compound with the chemical formula C9H10O2. It is a derivative of acetophenone, with a methoxy group attached to the para position of the benzene ring. This compound typically appears as a white to pale yellow crystalline solid with a characteristic sweet, floral, anise-like odor. It is moderately soluble in water and soluble in many organic solvents like ethanol and ether.

Industrially, 4-methoxyacetophenone is produced through the Friedel-Crafts acylation of anisole with acetyl chloride or acetic anhydride in the presence of a Lewis acid catalyst. Its primary application is as a fragrance ingredient, lending its distinct aroma to perfumes, soaps, and cosmetics. It also finds use as a flavoring agent in food products, contributing to anise or licorice notes. In some laboratory settings, it serves as a chemical intermediate in the synthesis of other organic compounds. Its relatively low toxicity and pleasant scent make it a common ingredient in consumer products.