2Formylthiophene

2-Formylthiophene, also known as thiophene-2-carbaldehyde, is an organic compound with the chemical formula C5H4OS. It is an aldehyde derived from thiophene, a heterocyclic aromatic organic compound. Structurally, it consists of a thiophene ring with a formyl group (CHO) attached at the second position of the ring. It is a pale yellow liquid with a distinct odor.

This compound is typically synthesized through the Vilsmeier-Haack reaction of thiophene, where thiophene is reacted with phosphorus oxychloride and dimethylformamide. Other methods of preparation exist, including the oxidation of 2-hydroxymethylthiophene.

2-Formylthiophene serves as a valuable intermediate in organic synthesis. Its aldehyde functionality allows it to participate in various reactions, such as condensation, oxidation, and reduction. It is commonly used in the preparation of pharmaceuticals, agrochemicals, dyes, and fragrances. For instance, it can be a building block for more complex heterocyclic systems or for molecules with specific biological activities. Its reactivity makes it a versatile reagent in the development of new chemical entities.