11p154

11p154 is a cytogenetic descriptor used in human genetics to designate a specific sub-band on the short arm (p) of chromosome 11. In karyotypes and genome annotations, chromosomes are divided into labeled bands that help localize genes, regulatory elements, and structural variants. The label 11p154 refers to a position within the distal part of the short arm and is used to report findings from methods such as karyotyping, fluorescence in situ hybridization (FISH), microarray analysis, and sequencing.

The precise boundaries and gene content of 11p154 can vary with different genome assemblies and individual variation. The broader 11p15 region, which includes 11p15.4, hosts a well-studied imprinted domain that plays a role in growth regulation and development. The most extensively characterized imprinted cluster in this vicinity is located at 11p15.5, where dysregulation is associated with Beckwith-Wiedemann syndrome and related growth disorders. Thus, 11p154 lies within a genomic neighborhood of clinical interest, though the specific phenotypes depend on the exact genetic changes and their impact on nearby genes.

In clinical and research settings, 11p154 is used as a reference point for describing chromosomal rearrangements, copy number variants, or sequence abnormalities. Investigations typically involve cytogenetic methods alongside higher-resolution genomic technologies to determine the exact content and potential clinical significance of the affected interval. For precise coordinates and gene content, researchers and clinicians refer to current genome builds such as GRCh38/hg38 and corresponding annotation databases.