vaspin

Vaspin is a protein that belongs to the serpin (serine protease inhibitor) superfamily and is encoded by the SERPINA12 gene in humans. It is produced by adipose tissue and circulates in the bloodstream, classifying it as an adipokine, a signaling molecule released by fat tissue that can influence metabolic processes.

Biological role and mechanisms of action are not fully understood. Vaspin is thought to act as an endocrine regulator of metabolism and insulin sensitivity. In preclinical studies, administration of vaspin to mice and rats has been shown to improve insulin sensitivity and glucose tolerance, suggesting a protective role against obesity-related metabolic disturbances. The exact protease targets and signaling pathways involved remain under investigation, and the receptor for vaspin has not been definitively identified.

Clinical associations and biomarker potential are the subject of ongoing research. In humans, circulating vaspin levels have been reported to correlate with metabolic state, but findings are not entirely consistent across studies. Some investigations have found higher vaspin concentrations in obesity and insulin resistance or impaired glucose tolerance, while other studies have observed different patterns in individuals with type 2 diabetes or after interventions such as weight loss. The variability may reflect differences in study populations, assay methods, and metabolic context.

Overall, vaspin is of interest as a potential biomarker for metabolic syndrome and as a candidate target for therapies aimed at improving insulin sensitivity. However, more research is needed to clarify its physiological role, identify its protease targets and receptor, and determine its value in clinical practice.