trombomoduliini
Trombomoduliini, known in English as thrombomodulin, is a transmembrane glycoprotein expressed predominantly on the surface of endothelial cells lining blood vessels. It serves as a key cofactor in anticoagulation by binding thrombin and altering its substrate specificity to favor activation of the anticoagulant protein C.
When thrombin binds to thrombomodulin on the endothelial surface, thrombomodulin facilitates the conversion of protein C
Structurally, thrombomodulin consists of an extracellular domain that binds thrombin, a single transmembrane region, and a
Genetics and clinical relevance: the THBD gene encodes thrombomodulin. Altered expression or function of thrombomodulin has