ticarcilín

Ticarcillin is a penicillin-class antibiotic effective against a broad spectrum of bacteria. It is a semisynthetic carboxypenicillin that functions by inhibiting bacterial cell wall synthesis. Ticarcillin is typically administered intravenously or intramuscularly. It is often combined with clavulanic acid, a beta-lactamase inhibitor, to extend its spectrum of activity to include bacteria that produce beta-lactamase enzymes, which would otherwise inactivate ticarcillin.

This combination, known as ticarcillin/clavulanic acid, is used to treat a variety of infections, including those of the respiratory tract, urinary tract, skin and soft tissues, and intra-abdominal infections. It is particularly useful against Gram-negative bacteria, such as Pseudomonas aeruginosa, as well as many Gram-positive bacteria.

Ticarcillin itself is susceptible to hydrolysis by beta-lactamases. Common side effects of ticarcillin include hypersensitivity reactions, gastrointestinal upset, and changes in blood cell counts. It is generally contraindicated in patients with a known allergy to penicillins or cephalosporins. The use of ticarcillin should be guided by susceptibility testing of the infecting organism. It is important to note that ticarcillin is not effective against atypical bacteria or viruses.