syntocinon

Syntocinon is a brand name for synthetic oxytocin, a peptide hormone identical to the natural oxytocin produced by the posterior pituitary. It is used in obstetrics to stimulate uterine contractions and to prevent or treat postpartum hemorrhage caused by uterine atony. It may be employed to induce labor or to augment labour when contractions are insufficient, and after abortion or delivery to promote uterine tone and reduce bleeding.

The medication works by binding to oxytocin receptors on uterine smooth muscle, triggering contractions. At higher doses or with prolonged use, oxytocin can have antidiuretic effects, which may contribute to water intoxication and hyponatremia if fluids are not carefully managed. Contractions that are too frequent or too strong (tachysystole) can compromise fetal oxygenation and safety.

Syntocinon is typically administered by intramuscular injection or as an intravenous infusion, with the dose and rate adjusted to the clinical situation and closely monitored by healthcare professionals. It is important to monitor the mother and fetus for signs of excessive uterine activity, fetal distress, fluid overload, or electrolyte imbalance.

Contraindications and cautions include hypersensitivity to oxytocin or formulation excipients. It should be used with caution in conditions where heightened uterine activity is undesirable, such as placenta previa, vasa previa, placental abruption, uterine scars from previous surgery, or known fetal/metal distress. It is generally avoided or used with extreme caution in such scenarios and under strict medical supervision.

Availability varies by country; Syntocinon is widely used worldwide as a standard oxytocic agent, supplied in formulations suitable for injection or infusion.