sulfadoxine
Sulfadoxine is a long-acting sulfonamide antimicrobial agent used primarily in combination with pyrimethamine for the treatment and prevention of malaria. It inhibits dihydropteroate synthase, an enzyme in the parasite folate synthesis pathway, thereby blocking DNA synthesis. When paired with pyrimethamine, which inhibits dihydrofolate reductase, the combination produces a synergistic blockade of folate metabolism in Plasmodium species.
Clinical use centers on malaria treatment in regions with susceptible parasite strains and on malaria prevention
Pharmacokinetics and administration are oral, with a long half-life that supports single-dose preventive regimens but can
Safety and resistance: adverse effects can include hypersensitivity reactions, rash, and hematologic effects such as megaloblastic