substratechanneling
Substrate channeling is a process in biochemistry in which intermediates produced by one enzyme are transferred directly to the next enzyme in a metabolic pathway without fully equilibrating with the surrounding solution. This direct handoff can occur within a single enzyme that contains multiple active sites, or more commonly within a multi-enzyme complex or metabolon where enzymes are physically associated.
The mechanisms of substrate channeling fall into several categories. In internal channeling, a substrate is passed
Examples and evidence include well-studied cases such as tryptophan synthase, where indole is transferred directly between
Substrate channeling is thought to improve catalytic efficiency, increase overall flux, prevent side reactions, and enable