stromaltargeting
Stromaltargeting refers to a therapeutic strategy focused on inhibiting or disrupting the function of stromal cells within a tumor microenvironment. The stroma is a complex network of non-cancerous cells, including fibroblasts, immune cells, endothelial cells, and extracellular matrix components, that surrounds and supports tumor growth. While cancer cells are the primary targets of many anti-cancer therapies, the tumor stroma plays a crucial role in tumor progression, metastasis, and resistance to treatment.
Stromal cells can promote tumor growth by secreting growth factors and cytokines that stimulate cancer cell
Stromaltargeting aims to neutralize these pro-tumorigenic activities of the stroma. This can be achieved through various