sphingosineksi
Sphingosine kinase 1 (SphK1) is an enzyme that plays a crucial role in the regulation of sphingolipid metabolism, a class of lipids that are essential for various cellular processes. SphK1 catalyzes the phosphorylation of sphingosine, a long-chain base, to sphingosine-1-phosphate (S1P), a potent bioactive lipid mediator. This reaction is the first step in the synthesis of ceramide-1-phosphate, a key intermediate in sphingolipid metabolism.
SphK1 is a type I membrane-bound enzyme that is widely expressed in various tissues, including the brain,
The activity of SphK1 is regulated by various factors, including calcium, sphingosine, and other lipids. SphK1
SphK1 has been the subject of intense research due to its potential as a therapeutic target. Inhibitors