sitoutumiskohtina
Sitoutumiskohtina, Finnish for "binding site," is a region on a macromolecule, typically a protein or nucleic acid, that provides specific chemical interactions with a ligand, substrate, or inhibitor, enabling selective binding. Binding at sitoutumiskohtina is governed by shape complementarity, chemical environment, and dynamics; the strength of binding is described by affinity, often quantified as a dissociation constant (Kd).
Sitoutumiskohtina can be located in functional regions such as active sites, where catalysis occurs, or in
The structural basis typically involves pockets or grooves formed by amino acid residues; non-covalent interactions such
Methods to identify and characterize sitoutumiskohtina include X-ray crystallography, nuclear magnetic resonance, cryo-electron microscopy, mutagenesis studies,
Examples include enzyme active sites binding substrates, receptors binding neurotransmitters, and viral proteases binding inhibitors. The