singleepitope
Singleepitope is a term used in immunology and vaccine research to describe approaches that focus the immune response on a single epitope of an antigen. In practice, singleepitope strategies aim to elicit antibodies or T cell responses directed primarily at that specific region, often by presenting the epitope in isolation or within a carefully designed scaffold or carrier.
Rationale for singleepitope designs is to concentrate immunity on a conserved or protective site, potentially overcoming
Methods used to realize singleepitope constructs include epitope discovery through structural biology, epitope mapping, and computational
Applications of singleepitope approaches appear in infectious disease research, where scientists aim to generate broadly neutralizing
Challenges include the reliance on epitopes that may require precise conformational presentation, the possibility of immune