sigdcelleanemi
Sigdcelleanemi is a hereditary red blood cell disorder characterized by the production of abnormal hemoglobin that can cause red blood cells to assume a crescent or sickled shape under low oxygen conditions. In many medical references, the term is used as an alternate name for sickle cell disease, reflecting its shared core features, though some regional glossaries distinguish a specific variant. The condition is typically inherited in an autosomal recessive pattern.
The disease arises from mutations in the beta-globin gene (HBB) on chromosome 11, most commonly a substitution
Clinical features include recurrent pain episodes (vaso-occlusive crises), chronic hemolytic anemia with fatigue and pallor, jaundice,
Diagnosis relies on blood tests: complete blood count showing anemia, peripheral smear with sickled cells, and
Management focuses on reducing symptoms and preventing complications. Pain control, hydration, and infection prevention are essential.