sequencestructurefunction
Sequence-structure-function is a foundational concept in biology describing how the linear sequence of a biomolecule encodes its three-dimensional structure, which in turn determines its biological role. The relationship is complex and context-dependent: small sequence changes can alter folding and activity, while different sequences can sometimes converge on similar structures and functions.
For proteins, the primary sequence of amino acids guides folding into hierarchical levels of structure—secondary, tertiary,
For nucleic acids, sequence dictates base pairing and the formation of secondary and tertiary structures. RNA,
Predicting structure from sequence is a central goal of bioinformatics and structural biology. Methods include homology