sebacamide

Sebacamide is the diamide derivative of sebacic acid (also known as decanedioic acid). It is formed when both carboxyl groups of sebacic acid are converted to amide groups, yielding a linear eight-carbon chain with amide functionality at each end. A representative structural depiction is H2N-CO-(CH2)8-CO-NH2, classifying sebacamide as a neutral, non-ionic diamide.

Preparation and properties: Sebacamide can be prepared by amidation of sebacic acid or its derivatives with ammonia or ammonium compounds, typically under heating. The resulting compound is a white to off-white waxy solid at room temperature. It is relatively non-polar due to the long hydrocarbon chain and shows limited water solubility while dissolving in many organic solvents.

Applications: In cosmetic science, sebacamide is used as a conditioning agent and texture modifier in skin and hair care formulations. It can contribute to slip, softness, and conditioning of hair fibers and may function as an emollient or thickener in creams and lotions. Its long aliphatic chain supports film-forming and conditioning characteristics without introducing charge.

Safety and regulation: Sebacamide is employed in cosmetic products within typical concentration ranges. Comprehensive toxicological data are limited; as a long-chain aliphatic diamide, it is not regarded as highly toxic under normal cosmetic use. Standard handling practices apply to avoid inhalation of dust and to prevent contact with eyes.

See also: adipamide, sebacic acid, amide derivatives.