receptortyrosinkinasvägar
Receptor tyrosine kinases are a large family of cell surface receptors that play crucial roles in cellular signaling. They are integral membrane proteins that, upon binding to their specific extracellular ligands, undergo a conformational change that activates their intracellular tyrosine kinase domain. This activation leads to autophosphorylation of the receptor itself and subsequent phosphorylation of downstream signaling molecules. This cascade of phosphorylation events relays signals that regulate a wide range of cellular processes including cell growth, differentiation, survival, and metabolism.
The extracellular ligand-binding domain of receptor tyrosine kinases is highly diverse, allowing for specific recognition of
Dysregulation of receptor tyrosine kinase signaling is implicated in numerous diseases, most notably cancer. Aberrant activation