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Racemization refers to the process by which a chiral molecule, one that exists as non-superimposable mirror images called enantiomers, is converted into a mixture containing both enantiomers. This transformation typically occurs when a chiral center loses its stereochemical integrity, resulting in an equal or near-equal distribution of the two possible enantiomeric forms. The resulting mixture is known as a racemate or racemic mixture, where the optical rotation of the compound becomes zero due to the equal and opposite contributions of the enantiomers.
Racemization can occur through various mechanisms, including chemical, enzymatic, or thermal processes. In chemical racemization, a
Racemization is a significant consideration in organic synthesis, pharmacology, and biochemistry. In drug development, racemization can