proteogenesis

Proteogenesis refers to the spontaneous formation of proteins or protein-like structures from non-proteinaceous precursors without the involvement of biological machinery such as ribosomes or enzymatic catalysis. This process contrasts with traditional biogenesis, where proteins are synthesized through the central dogma of molecular biology—transcription of DNA into RNA followed by translation into polypeptide chains.

The phenomenon of proteogenesis has been observed in various inanimate environments, including meteorites, interstellar dust, and laboratory simulations of prebiotic conditions. Experiments have demonstrated that under high-energy environments, such as those produced by ultraviolet radiation, electric discharges, or thermal heating, simple organic molecules like amino acids can polymerize into peptide chains. These chains may exhibit properties resembling proteins, including secondary structures like alpha-helices or beta-sheets, though they lack the precise amino acid sequences and functional complexity of biologically synthesized proteins.

While proteogenesis does not produce functional proteins capable of performing biological roles, it suggests that the building blocks of life could arise spontaneously under certain conditions. This concept supports hypotheses about the origin of life, proposing that early Earth or other planetary bodies may have hosted similar processes before the emergence of cellular life. Research in this area combines astrobiology, chemistry, and molecular biology to explore how life’s fundamental components might have formed abiotically.

Critics argue that proteogenesis alone cannot account for the complexity and specificity of biological proteins, which require precise genetic encoding and enzymatic refinement. Nonetheless, studying proteogenesis provides insights into the chemical feasibility of prebiotic protein formation and contributes to understanding the broader context of life’s origins.