propeptidos

Propeptides are inactive precursor forms of peptides or proteins. They are synthesized as larger polypeptide chains and undergo post-translational modification, typically proteolytic cleavage, to become active. This processing step removes the propeptide sequence, revealing the functional mature peptide or protein. Propeptides can serve several roles, including assisting in proper folding, targeting the protein to specific cellular compartments, or facilitating secretion from the cell. They can also act as inhibitors of the mature protein's activity until the propeptide is removed. Examples of propeptides include those found in insulin, collagen, and certain enzymes. The removal of propeptides is a tightly regulated process essential for biological function. The term propeptide is often used interchangeably with proprotein or precursor protein, though it specifically refers to the peptide portion that is cleaved off. This mechanism of producing inactive precursors is a common strategy in biological systems to control protein activity and ensure correct maturation.