prodrugaktivointia
Prodrug activation is a crucial process in pharmacology where an inactive prodrug is converted into its active form within the body. This strategy is employed to overcome various challenges associated with drug delivery, efficacy, and safety. Prodrugs are essentially designed as temporary modifications of a drug molecule, rendering it inert or less active until a specific biological trigger causes its transformation into the parent drug.
The activation process can occur through enzymatic or non-enzymatic mechanisms. Enzymatic activation involves the action of
The primary reasons for utilizing prodrug activation include improving oral bioavailability, enhancing drug solubility, prolonging drug