polymercorelipidshell

Polymercorelipidshell refers to hybrid nanomaterials that consist of a polymer-based core encased by a lipid shell. This architecture merges the drug-loading capacity and controlled release properties of polymeric nanoparticles with the biocompatibility and membrane-mimicking surface of lipid coatings.

In composition, the core is typically made from biodegradable polymers such as PLGA (poly(lactic-co-glycolic acid)) or other polyesters, which allow encapsulation of small molecules, proteins, or nucleic acids. The surrounding lipid shell commonly comprises phospholipids, cholesterol, and sometimes PEGylated lipids to impart stealth characteristics and reduce protein adsorption. The lipid layer can also be functionalized with targeting ligands to direct delivery to specific cell types or tissues.

Fabrication methods are generally two-step processes. A polymeric core is formed first, using techniques such as nanoprecipitation or emulsification, followed by layering or fusion with lipid components to create the shell. The resulting particles typically fall in the tens to hundreds of nanometers in diameter and can exhibit surface properties tuned for circulation time, stability, and cellular uptake.

Applications focus on therapeutics and diagnostics. Polymercorelipidshell particles are explored for targeted drug delivery, gene or mRNA delivery, and as imaging or theranostic agents due to their capacity for co-encapsulation and surface modification. Benefits include improved stability, controlled release, and enhanced biocompatibility relative to some purely polymeric or lipid-only systems, while challenges involve manufacturing complexity and shell integrity under physiological conditions.