perindítani

Perindopril is a medication belonging to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is primarily used to treat high blood pressure, also known as hypertension, and heart failure. It can also be used to prevent further cardiovascular events in certain individuals with established coronary artery disease.

The mechanism of action of perindopril involves blocking the angiotensin-converting enzyme. This enzyme plays a crucial role in the renin-angiotensin-aldosterone system, which regulates blood pressure and fluid balance. By inhibiting ACE, perindopril reduces the production of angiotensin II, a potent vasoconstrictor. This leads to vasodilation, or widening of blood vessels, which lowers blood pressure. Additionally, it decreases the secretion of aldosterone, a hormone that promotes sodium and water retention, further contributing to blood pressure reduction.

Perindopril is typically administered orally, usually once daily. It is available in various dosage strengths. Common side effects can include a dry cough, dizziness, headache, and fatigue. More serious side effects, though less common, can include angioedema, a swelling of the face, lips, tongue, or throat, which requires immediate medical attention. It is important for patients to discuss their medical history and any current medications with their healthcare provider before starting perindopril to ensure it is appropriate and safe for them.