p130Cas
p130Cas, also known as BCAR1 or Crk-associated substrate, is a cytoplasmic adaptor protein that localizes to focal adhesions. It acts as a scaffold that links integrin-mediated adhesion signals to intracellular signaling pathways, thereby influencing the organization of the actin cytoskeleton, cell motility, proliferation, and survival. It is a member of the Cas family of proteins that coordinate cues from the extracellular matrix with intracellular responses.
Structurally, p130Cas features an N-terminal SH3 domain, a long central substrate domain rich in tyrosine residues
Activation and signaling occur when integrin engagement and growth factor signals promote Src family kinase activity,
Biological and clinical relevance includes roles in cell adhesion, migration, and mechanotransduction, with weight given to