ossalacetato
Oxaloacetate, sometimes written ossalacetato, is a four‑carbon dicarboxylic acid that bears a keto group and serves as a central metabolite in cellular metabolism. It is primarily formed in the mitochondria by the oxidation of malate and participates in multiple pathways, including transfer between subcellular compartments via shuttle systems such as the malate–aspartate shuttle. At physiological pH, oxaloacetate exists mainly as negatively charged derivatives, which influences its transport and compartmentalization.
In metabolism, oxaloacetate has key roles in both the citric acid cycle and gluconeogenesis. In the cycle,
Physiological significance and variation: oxaloacetate serves as a hub linking energy production, carbon skeleton provisioning, and