orotat

Oratat is the term used for salts or esters of orotic acid, the pyrimidine carboxylic acid that serves as an intermediate in de novo pyrimidine synthesis. Common oratate salts include calcium orotate, magnesium orotate, sodium orotate, and potassium orotate. These compounds are typically used in dietary supplement formulations to deliver orotate.

Biochemically, orotate is an intermediate in the production of pyrimidine nucleotides. In humans and other organisms, orotate is converted to uridine monophosphate (UMP) through a pathway that involves orotate phosphoribosyltransferase and subsequent decarboxylation steps. Because of this role, orotate-containing compounds are sometimes discussed in the context of nucleotide synthesis and cellular proliferation, though the body can generate orotate via multiple routes.

Use and evidence: Oratate salts are marketed as nutritional supplements intended to support bone health, athletic performance, or general well-being. However, robust clinical evidence for clear or consistent benefits is limited. They are not considered essential nutrients, and claims regarding enhanced performance or health outcomes are not uniformly supported by high-quality trials. As with many supplements, product quality, purity, and labeling can vary, and high-dose use may cause adverse effects such as gastrointestinal upset. Individuals with kidney disease or those taking certain medications should exercise caution and consult a healthcare provider.

Chemistry and availability: Oratates are typically water-soluble salts of orotic acid and are sold in various forms, with calcium orotate and magnesium orotate among the common examples. They are available as dietary supplements in many jurisdictions and are not generally prescribed medicines.